报告题目(中文)：聚合物纳米医药的研究
报告时间：2014-12-01 13:30
报告地点：东区材料楼520

报告题目(英文)：Recent synthetic advances that facilitate control over polymer structure and functionality have led to the advent of polymer theranostics; devices capable of both diagnosing disease and providing a treatment. While the potential application of such devices is tremendous, in vivo monitoring remains a significant scientific challenge. In this report we present recent work on the synthesis of hyperbranched (meth)acrylates for imaging and cancer therapy. While the ultimate aim in polymer theranostics is the development of a multi-modal, multi-functional, biodegradable delivery device with the possibility of facile conjugation of therapeutics, imaging agents and targeting moieties, current methodologies are plagued by poor drug loading, inefficient cell uptake, targeting inefficiencies, synthetic complexities or a combination of all of these factors. Here, we discuss the properties of hyperbranched polymers and show how they offer a unique solution to many of these problems: they are ideal for this technology because they have the potential to combine many different functionalities (and hence chemistries) into a single molecule; their structural non-uniformity, yet highly controlled size, volume and intramolecular dynamics facilitates structural rearrangements not possible in many other theranostic analogues. In this presentation we demonstrate how RAFT chemistry can be used to introduce multiple functionalities within a molecule that can subsequently be utilized for drug conjugation or application in magnetic resonance imaging (MRI) by correct choice and placement of monomers. In this report we present the synthesis and characterisation of such polymers and describe both in vitro and in vivo data on the application of these molecules as drug delivery devices (both siRNA and chemotherapies) and as multimodal imaging agents incorporating modalities such as 1H and 19F MRI, PET and fluorescence. In conclusion, hyperbranched polymers for drug delivery and imaging have been synthesised by a controlled free radical technique with the overall aim of developing the field of polymer theranostics. Various ligation technologies have been used to attach cell-targeting moieties, drug molecules and other markers to the molecule that significantly enhance both the both diagnostic and drug delivery potential of the theranostic.

报告人简介(中文)：Kris Thurecht博士于2005年9月获得昆士兰大学高分子化学博士学位，随后在英国诺丁汉大学从事博士后研究，师从于Steve Howdle教授。现任澳大利亚的昆士兰大学研究理事会(ARC)的青年研究员，是高级成像中心(CAI)和澳大利亚生物工程和纳米技术研究所(AIBN)的负责人。由于Thurecht博士卓越的科学才能和在高分子"治疗诊断学"研究领域做出的突出贡献，分别获得2010年昆士兰大学基础研究卓越奖和2012年昆士兰杰出青年科学家奖。自2005年9月取得博士学位后， Thurecht博士的基金资助超过3000万澳元，其中包括澳大利亚、英国以及澳大利亚研究理事会(ARC)、国家卫生和医学研究委员会基金和癌症基金会资助。Thurecht博士共发表了75篇著作，合作发明专利两项。Thurecht博士是澳大利亚研究理事会生物-纳米科学和科技卓越研究的主要开拓者，现任澳大利亚皇家化学协会昆士兰聚合物团队的主席。Thurecht博士的研究侧重于发展聚合物和纳米粒子器件在纳米医学上的应用。Thurecht博士团队的工作跨越化学、材料、生物学和成像科学领域，从中探寻在生物体内，纳米材料属性如何影响它们的功能。